منابع مشابه
Metabolism of Bence Jones Proteins.
Bence Jones proteins are molecules of about 40,000 mol wt present in the urine of many patients with plasma cell malignancy. These microglobulins, which are synthesized in plasma-cell tumors (1, 2), share many immunochemical and physicochemical features with the larger 6.6 S y-globulins. That Bence Jones proteins are similar to or identical with components of the larger y-globulins has been sug...
متن کاملThe Nature of Bence-jones Proteins
The chemical relations among Bence-Jones proteins, myeloma proteins, and normal gamma-globulins have been investigated by a variety of means. Starch gel electrophoresis in 8 M urea of reduced alkylated Bence-Jones proteins yielded patterns of bands corresponding to those of the light (L) polypeptide chains of the dissociated myeloma protein from the same patient. One instance in which this corr...
متن کاملHuman Antibody Reacting with Bence Jones Proteins
The light (L) polypeptide chains of the human T-globulins carry antigenic determinants designated as group 1 or 2 (1-3). Allotypic determinants designated InV have been found in association with the L chains of 3,,-globulin (4). Natural ly occurring human ant ibody directed toward L chain determinants has been described in detail only for the InV antigens (5). The present studies utilize human ...
متن کاملThe ultraviolet rotatory dispersion and conformation of Bence-Jones proteins.
The optical rotatory dispersion of five individual specimens of Bence-Jones proteins was investigated, including the far ultraviolet spectral zone. The Mo5tt constants (bo) were determined, and either low positive or low negative values were found. The rotatory dispersion curves of all specimens had flat negative minima at 220 to 235 rnp and positive maxima at 204 to 212 rnp. Denaturation with ...
متن کاملBence Jones proteins identified by immunofixation electrophoresis of concentrated urine.
addressed some recently recognized problems in testing concentrated urine for monoclonal free light chains of immunoglobulins, i.e., Bence Jones protein (BJP), by high-resolution elec-trophoresis (lIRE) and immunofix-ation electrophoresis (IFE). When BJP is present in low concentrations, poly-clonal free light chains can interfere with identification of the protein either by causing a dense bac...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1964
ISSN: 0021-9738
DOI: 10.1172/jci104884